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Literature suggests that a statistical based method can account for variability and a large number of influencing factors, and could be a promising alternative.
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Furthermore, given the need for a short time window, no frequency based method can be applied on account of loss of resolution.
Alignment based methods can be further divided into sequence alignment based and structural alignment based methods.
The method can account for any number of reflecting paths.
This is another big challenge for which we think that our method can account for.
Unlike distance based methods, they can account for any conceivable evolutionary rate, and any number of differences per site.
Depending on where airlines are based, fuel can account for 10-30% of operating costs.
Traditional case-mix adjustments via multivariate regression based methods cannot completely account for the selection bias.
In general, using these methods for predictions can be problematic without including biologically based mechanistic descriptions that can account for dose and species differences.
Alternatively, one can rely on phylogeny reconstruction methods that can account for compositional heterogeneity, and thus ameliorate their confounding influence.
Unlike standard methods based on overall estimates of Ka /Ks, codon-based models can account for among-site variation in Ka /Ks by assigning sites to discrete rate categories.
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