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Here we use a phylogenetically based maximum likelihood procedure to identify shifts in rates of nucleotide substitutions.
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Finally, we used a pedigree-based maximum likelihood procedure to estimate the heritability of persistent colonization by defining heritability as the proportion of the total trait variance attributable to the additive effects of genes.
The method is based on maximum likelihood procedures to estimate significant changes in the site-specific shift.
Estimates of heritability, utilizing a variance component approach based on maximum likelihood procedures, were calculated in SOLAR version 2.1.4 [ 31].
This method is based on maximum likelihood procedures to estimate significant changes in the rate of evolution after the emergence of two paralogous sequences.
The method is based on maximum likelihood procedures to estimate significant changes in the site-specific shift of evolutionary rate or site-specific shift of amino acid properties after the emergence of two paralogous sequences.
The method is based on maximum likelihood procedures to estimate significant changes in the site-specific shift of the evolutionary rate or the site-specific shift of amino acid properties after the emergence of two paralogous sequences.
This method is based on maximum likelihood procedures to estimate significant changes in the site-specific shift of evolutionary rate or site-specific shift of amino acid properties after the emergence of two paralogous sequences.
Heritability estimates were obtained using a variance component approach based on maximum likelihood procedures implemented in the SOLAR (Sequential Oligogenic Linkage Analysis Routines) software package (http://www.sfbr.org/solar/index.html).html
Parameters were estimated for the CFA model based on the maximum likelihood procedure (sometimes called path analysis) involving fitting the variances and covariances among observed scores.
Infection parameters describing the transmission potential and the duration of the stages of the disease are obtained through a maximum likelihood procedure based on the empirical data of the H1N1 international seeding events (see Figure 1A).
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