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The upgrading of ethylene oxide was based largely on results in exposed workers that showed induction of chromosomal aberrations in peripheral lymphocytes, the presence of micronuclei in bone marrow cells, and hemoglobin adducts in blood samples.
TGF-β1 has been considered an anabolic factor to articular chondrocytes, based largely on results from in vitro and ex vivo experiments in which TGF-β1 can stimulate chondrocytes to synthesize and release proteoglycans and type II collagens.
However, these results are based largely on results from case-control studies and only a small number of these studies provide data for postmenopausal women separately from premenopausal women.
This approval was based largely on results from the Xeloda in Adjuvant Colon Cancer Therapy (X-ACT) trial in which 1987 patients with previously resected stage III colon cancer were randomized to either capecitabine at 1250 mg/m (1004 patients) twice daily or bolus 5-FU plus leucovorin via the Mayo regimen (983 patients).
The test data set is based largely on results of Yanai et al.[ 14], who completed gene perturbation experiments followed by transcript abundance analysis for all genes in the network, and yeast one hybrid (DNA binding) analysis for all transcription factors and the upstream sequences for each gene in the network.
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Guidance from the National Institute of Health and Clinical Excellence (NICE) and similar bodies on the effectiveness and cost-effectiveness of both drugs and complex interventions, including rehabilitation, is therefore based largely on the results of RCTs where these results are available [ 6].
Although university entrance is based largely on the results of a national exam, universities have some discretion in admissions.
Those figures, unlike Bryant's, are based largely on the results of a survey taken more than 20 years ago.
The study of animals with diseases similar to those that affect man has increased knowledge of the diseases in man; knowledge of nutrition, for example, based largely on the results of animal studies, has improved the health of animals, including man.
Three paddlers will be officially selected to the team in each of the four Olympic classes in the coming days, based largely on the results of the last three days of racing.
LCUSD retained the No. 2 spot behind San Marino Unified despite a five-point drop in the local district's overall Academic Performance Index score, based largely on the results of state tests taken by students in the spring.
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