Insulin-based interventions have shown very promising results in mice [ 14– 17] and based on these findings, human clinical trials with insulin are currently on the way [ 18].
Behavioral intervention technologies (BITs) designed to prevent depression in adolescence, especially standalone web-based interventions, have shown mixed outcomes, likely due to poor intervention adherence.
Although early exercise-based interventions have shown clinical benefit in terms of functional outcome [ 6], this effect is by no means universal across different healthcare models [ 7- 9].
Web-based interventions have shown to be well accepted by participants [ 29, 30] and to be effective in the acute treatment of MDD [ 12] as well as in reducing depressive symptoms both in adults and adolescents [ 31, 32].
Second, a number of studies using mindfulness-based interventions have shown that they reduce stress and have used this measure, so we could 'benchmark' the impact of the online mindfulness course against the existing evidence-base.
As exercise interventions have shown effectiveness in improving schizophrenia psychopathology [ 11], and mindfulness-based interventions have shown preliminary but promising effects in patients with psychosis [ 51, 52], dismantling studies that separately evaluate the effects of different components of yoga seem warranted.
For such conditions, home based interventions have been shown to lower mortality rates related to falls [ 28, 39] and the risk and rate of falls in older adults [ 40], reduce the number of nursing home admissions and hospitalisations, and decrease hospital length of stay.
Pharmacist based interventions have effectively improved management of hypertension.
