This multi-compartmental model of a DA neuron with a branching structure was developed and calibrated based on in vitro experimental data to explore the effects of different levels of activation of NMDA and GABAA receptors as well as the modulation of the SK current on the firing activity.
Data on carotid artery hemodynamics are usually based on simplified, computer-based, or in vitro experimental models, most of which assume that the velocity profiles are axially symmetric away from the carotid bulb.
Based on these preclinical in vitro experimental data, we believe that the sequence and infusion times regarding docetaxel and ifosfamide, as applied in the present study, might lead to potential in vivo synergism between these two drugs (Kearns et al, 1995).
Clinical cases that describe the application of LLLT to treat BRONJ have been reported, based on in vivo and in vitro experimental studies that demonstrated a biostimulative effect [7, 42, 43].
For instance, based on in vivo and in vitro experimental findings, it has been hypothesized that oxidative stress can regulate both DNA methylation and DNA hydroxymethylation processes by impairing one-carbon (Lee et al. 2009) and citric acid metabolism (Chia et al. 2011) pathways, respectively.
In vitro experimental design based on the model analysis results could be the first step in confirming the predictions about the dynamics of the components of interest.
This conclusion is based upon observations using numerous in vivo and in vitro experimental systems of which murine BALB/c 3T3 T mesenchymal stem cells represent an excellent in vitro model.
Based upon these association observations and considerable amounts of in vivo and in vitro experimental evidence [ 198, 199], several mechanistic hypotheses have been proposed to explain these phenomena.
All the clones used for purification and in vitro experimental analysis were devoid of mitochondrial leader sequence based on the reported mature forms.
"In vitro" experimental results are also presented.
