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Regulatory T cell (Treg) based immunotherapy is a potential treatment for several immune disorders.
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Treg based immunotherapy is of great interest to facilitate tolerance in autoimmunity and transplantation.
The explanation for the low level of treatment success following IL-2 based immunotherapy is probably extremely complex.
The possibility of using MC1R for antibody or T cell based immunotherapy is dependent on how selectively this receptor is expressed in melanomas vs normal tissues.
Together these data indicate that enhancement of intratumoral TNFα levels via T cell based immunotherapy is feasible and attractive via different methods.
Recently, CpG based immunotherapy are intensively investigated.
These results provide the first clinical evidence to demonstrate that GPC3 peptide-based immunotherapy is a promising treatment for patients with ovarian CCC.
Young TIL-based immunotherapy can be reserved for the treatment of NPC patients from whom tumor biopsy tissues can be obtained, whereas EBV-specific CTL-based immunotherapy is a better choice for NPC patients from whom tumor biopsy tissues can not be obtained.
DC based immunotherapies are thus currently considered a particularly promising approach for cellular immunotherapy.
The mAb based immunotherapies are now standard of care in an increasing number of human cancers including Erb2+ breast cancer, Non-Hodgkin's Lymphoma, colon cancer and others [1], [6], [7].
However, T cell based immunotherapies are limited by insufficient frequencies of tumour infiltrating T cells in NSCLC [ 33].
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