We have also shown that the forced repression of Tcl1 primarily affects ES cell proliferation, but not differentiation, based on morphology and microarray-based gene expression patterns (Supplemental Table S10).
Microarray-based gene expression patterns were confirmed for a subset of 10 genes (Figure 3A, Table S2) with known or suspected roles in immunity, by using qRT-PCR.
Some use time-based gene expression patterns to identify transcription factors activated at specific time points [ 4, 5] to help predict the response network.
Comparison of the microarray-based gene expression patterns between CD3+ T cells, and the CD4+ and CD8+ subsets revealed largely conserved, but not identical, transcriptional patterns.
Thus, these advances have offered important new insights and computational tools for mining image-based gene expression patterns captured by ISH, which we extend by conducting a detailed analysis of the information contained in ISH images, and how it can be captured in a good feature representation format.
Perou et al. [ 18] were the first to describe breast cancer subtypes based on gene expression patterns and it was found that these subtypes (luminal-like, basal-like, Her2-enriched and normal-like) have significantly different survival times [ 19].
In fact, based on correlations between patterns of HERV-W gag expression, dendrograms could be constructed resembling those based on gene expression patterns.
We hypothesized that computational analysis of multiple PD microarray data can be used to identify certain sets of PD-associated marker genes based on gene expression patterns.
Differences in carbohydrate metabolism between the two strains were also visible based on gene expression patterns in different growth phases.
Based on gene expression patterns alone, the SPC gene set could be used to sort samples from normal adult kidneys by the anatomical regions from which they were dissected.
