For instance, PLGA-based formulations such as biodegradable microspheres are able to bypass the GI tract and allow enhanced bioavailability of molecules with a short half-life.
Tailored pH-responsive drug release in the gastrointestinal tract can be achieved with various chitosan-based formulations such as nanoparticles, microspheres, hydrogels and nanocomposites.
Of the many antimicrobial agents available, iodophore-based formulations such as povidone iodine have remained popular after decades of use for antisepsis and wound healing applications due to their favorable efficacy and tolerability.
Other ARV-based formulations such as gel, vaginal rings, and injectables will also have, at a minimum, the initial and ongoing HIV testing components, if not the initial lab tests depending on the formulation.
The most important category in advanced DDS is lipid-based formulations such as lipid solutions, lipid suspensions and self-emulsifying lipid formulations 3, 4. The lipid-based formulations in general are well recognized as a frontline formulation technology to handle the poorly water-soluble compounds.
Indeed, we attained only small ceramic particles (rather than complete scaffolds) in preliminary experiments using traditional water-based formulations such as polyvinyl alcohol as the slurry binder (data not shown), likely, because the ceramic scaffold shrank during sintering and was therefore broken up by the resin lattice struts.
Out of all the methods used for establishing IVIVC for lipid-based formulations, in vitro lipolysis plays a major role due to its capability to simulate the most important steps in the absorption of lipid-based formulations such as dispersion and digestion.
This representation is very useful for numerical methods which are based on boundary-integral formulations such as boundary-element method since the numerically evaluated part is not responsible for the singularity.
Protein formulations based on crystallized proteins may have better properties than current protein formulations, such as lyophilizates or aqueous solutions.
The use of polymers as precipitation inhibitors is not only limited to lipid-based formulations but can also be extended to other formulations such as solid dispersions and controlled release tablet formulations.
Although Kampo formulations are clinically used in various disease areas, and such use is primarily based on classic clinical theories, evidence-based clinical applications have begun to be established in recent years through the elucidation of the mechanisms of action of formulations such as Daikenchuto [ 14].
