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If their conclusions are based entirely on sequence assemblies (from NGS of ancient DNA), then they need to be backed up by additional experiments.
Current homology search tools for structured RNAs are either based entirely on sequence similarity (such as blast or hmmer) or combine sequence and secondary structure.
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Both the miRNAs target the motifs based entirely on the seed sequence with little or no base-pairing to the 3' region [ 64].
The absence of EST data for ceh-63 was consistent with the very restricted expression driven by the predicted promoter for this gene, but meant that the predicted exon/intron structure of the gene model was based entirely on the genomic sequence.
The initial release of the goat genome sequence is based entirely on short-read de novo sequencing of a Yunnan Black goat that yielded a ~2.66 Gb assembly of 284,683 scaffolds (N50 = 3.06 Mb).
However, the only currently available mouse genome is based entirely on the B6 strain sequence.
CRISPRmap was designed for comprehensive classification of all known (i.e., publicly available) CRISPR cassettes based entirely on the repeat properties (sequence and secondary structure).
We have more than doubled the number of sequenced toxins for this species and created extensive genomic resources for snakes based entirely on de novo assembly of Illumina sequence data.
We have introduced an efficient new approach that enables prediction of protein-protein interactions on a whole genome scale based entirely on information that can be derived from primary sequence data.
Here we report the development of a much simplified sequence-independent cloning technology based entirely on the polymerase extension mechanism.
The decision on one or two views was based entirely on density.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com