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This could have resulted in some children receiving lower than recommended doses of SP reducing the protective efficacy of IPTc and some children receiving more than recommended dose of SP. However, in a community volunteer based delivery system an age based dose regimen is easier to implement than a weight-based dose regimen.
However, for certain clinical situations TPS based dose calculations are currently associated with systematic deviations due to lack of corrections for heterogeneities and scatter conditions.
Antalgic radiotherapy for bone metastases might be improved by implementing biological information in the radiotherapy planning using 18F-FDG-PET-CT based dose painting by numbers (DPBN).
Pegylated IFN- α2a (fixed dose 180 ug) or pegylated IFN-α2b (weight based dose, 1.5 ug/kg of body weight) was injected subcutaneously weekly.
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There have been other traditional cell based dose-response techniques historically used.
These results provide a simple biologically based dose-response model and suggest that chemicals which act mechanistically like E2 may also show no threshold dose.
Biologically based dose-response (BBDR) models accounting for these biological switches would improve risk assessment for many nonlinear processes in toxicology.
In the carbohydrate-based dose group, prandial insulin was based upon the following equation: carbohydrate-to-insulin ratio (CIR) = 400/TDD, as reviewed previously (20).
Quantitative approaches to use in estimating risk, including PBPK-based dose estimates, linear and nonlinear extrapolation, and biologically based dose response modeling.
This allowed us to calculate an induction dose based on a clinical endpoint rather than an arbitrary weight-based dose.
Patients given weight-based dose of PCC (concentrated II, VII, IX, X).
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