This commentary highlights the recent work published in journal Nature on the structural based discovery of novel analgesic compounds for opioid receptors with minimal effects.
This paper provides an introduction and overview of literature based discovery (LBD) in the biomedical domain.
The metadata fields, which describe the spatial content of the hazard/susceptibility and risk maps, are embedded within the content field of the standard metadata format, since they enable a content-based discovery of the maps as described below.
This example, based on the discovery of the planet Neptune, effectively highlights the limited prospects for actual falsification, but may be under-appreciated as an example of corroboration.
In this paper, we consider the multi-symplectic Runge Kutta (MSRK) methods applied to the nonlinear Dirac equation in relativistic quantum physics, based on a discovery of the multi-symplecticity of the equation.
The role of aligned dislocations in improving the hydrogen absorption/desorption properties of Ti-22Al-27Nb Ti-22Al-27Nb Ti-22Al-27Nbiscovery of the similarities between the strain aroundiscussedcrew dislocations and that induced basede fonmation of hydiscovery
The choice of 30 samples was based on empirical discovery of the minimum number of one second samples needed to provide a stable average score, as follows.
Regenerative medicine and its exceptional potential in clinics [ 1– 4] are based on the discovery of the properties of stem cells.
The definitive cure of ARVC/D will be based on the discovery of the molecular mechanisms that are involved in the etiology and pathogenesis of the disease.
This hypothesis was based on the discovery of the giant sauropod Paralititan from the Cenomanian of Egypt but was seen to be of general applicability.
Based on the discovery of the new di-phenyl-pyrazole (DPP) lead structure (Fig. 1), a focussed compound library was generated.
