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In order to solve the first challenge and maintain a single fiber based design with a small overall probe diameter and high collection efficiency, we chose to use a custom double-clad fiber (DCF) with a 9 µm diameter core, 180 µm diameter inner cladding and 200 µm diameter outer cladding.
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We used a population based design with participants from two regions in eastern Finland.
Compare this against JBOF based design with 2 CPU + Y DRAM + 60-240 TB SSD.
The population based design in a country with universal healthcare reduced selection biases stemming from selective inclusion of specific hospitals, health insurance systems, or age groups.
Despite these limitations, we believe that our study, based on structured collection of information with a hospital based design combined with careful considerations of possible biases, represent findings of importance.
To our knowledge this is the first epidemiological study with a population based design investigating the risk for injuries in patients with a history of LCPD.
A major strength of the present study is the nationwide population-based design with a very small proportion of unidentified fathers (around 1%), although some misclassification of paternity, as in all studies based on self-reported information of fatherhood, is expected.
International Workshop on Model-Based Design with a Focus on Extra-Functional Properties (MBDEFP), 2011.
Here, we employed structure-based design with a focused chemical library to discover specific MRE11 endo- or exonuclease inhibitors.
The strengths of this study are the interventional, non-selected, population-based design with a large number of participants.
The advantages of this study include a population-based design with a high participation rate, which reduces the risk of selection bias and facilitates generalisation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com