The problem of reliability based design of structures subjected to partially specified random earthquake loads is considered.
By considerably reducing the number of time history analyses for assessment of structural response at different intensities, this procedure tends to pave a way for practical performance based design of structures.
The displacement based design of RC structures has been addressed increasingly in recent years, and the displacement based design of multiple degree of freedom RC structures has been the main philosophy of these approaches.
Numerical based design of geometrical structures is common when studying systems involving heat exchangers, a central component in several fields, such as industrial, vehicle and household systems.
Structure based design of subtype selective D2R antagonists requires high resolution crystal structures of the receptor and pharmacological tools promoting a better understanding of the protein-ligand interactions.
For the multi-layer laminated plates, it is observed that neglecting the statistical correlation would result an 15 20% overestimation on the laminate failure probability, which indicates the importance of consideration of the statistical correlation in the process of reliability evaluation or reliability based design of plain-weave composite structures.
The three-dimensional structure of proteins is central to many applications, such as structure-function studies, site-directed mutagenesis, or structure based design of active compounds.
This virtual model may provide helpful insights into the structure based design of other (more efficient and possibly selective) carborane-based CA IX inhibitors.
DOI: http://dx.doi.org/10.7554/eLife.00857.030 Amyloid fibers differ fundamentally in structure from the enzymes and signaling proteins that are the traditional targets in structure based design of binding compounds, and thus their pharmacophores might be expected to differ fundamentally as would the types of compounds that bind.
This would enable structure based design of e.g. an inhibitor library focussed on the likelihood of cross-reactivity.
