Suggestions(2)
Exact(9)
In the recent trials by Wilkowski and colleagues, further escalation of Gemcitabine based CRT by Cisplatin (compared to 5-FU based CRT) in unresectable LAPC showed significantly higher grade 3 4 RTOG toxicity without improvement of survival rates [ 33].
The trial randomised 267 patients to either preoperative 5FU based CRT (n = 130) or postoperative CRT (n = 137) [20].
These show high p21 and CD166 expression at the pretreatment biopsy were associated with tumor regression and poor prognosis in patients treated with 5-FU based CRT.
Oxaliplatin based CRT has been tested in Phase II trials, both in the neo-adjuvant and definitive treatment of oesophageal cancer [ 10- 16].
In summary, high p21 expression was associated with non-complete pathologic response and poor disease free survival outcome in patients with 5-FU based CRT.
A future phase III study will be conducted to compare GEM monotherapy and S-1 based CRT with or without induction GEM, depending on the results of the JCOG1106 study.
Similar(51)
The same group analyzed a consecutive series of 102 patients with NPC treated by either radiotherapy or cisplatin-based CRT according to clinical stage, and found that patients with high-TLG tumors were at significantly higher risk of death (hazard ratio 4.911; 95% confidence interval, 1.031 23.400) compared with patients with low-TLG tumors, after adjustment for age, sex, and clinical stage 28.
The WiSE-CRT study successfully documented the feasibility of delivering LV endocardial-based CRT using wireless ultrasound energy transfer.
Based on the available data for the efficacy of standard treatment, a survival rate of 60% after 9 months was expected after 5-FU-based CRT in the reference arm.
In rectal cancer, low TS gene expression has been found to correlate significantly with tumour response after neoadjuvant 5-FU-based CRT (Jakob et al, 2005).
Forty-six patients received paclitaxel-based CRT.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com