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Gene silencing therapies are also used to deliver short interfering RNA (siRNA) into central nervous system (CNS) while polylysine dendrimers D3 and D5 [ 73] and melittin-grafted HPMA-oligolysine based copolymers are also used for gene delivery [ 73].
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Copolymers are also able to induce responsive properties in membranes.
Current challenges in the area of block copolymers, nanotechnology and potential applications of linear dendritic block copolymers are also considered.
Hydrolytic degradation studies of selected copolymers were also performed.
The effect of macromolecular architecture on the association behavior of the copolymers was also examined.
In vitro drug release and cytotoxicity of paclitaxel-loaded micelles from these copolymers were also investigated.
Combining PAMAM with other amphiphilic block copolymers was also an approach for co-delivery.
The molecular weight of the copolymers is also sensitive to the concentration of CHO in the feed for the complexes.
Block copolymers bearing cholic acid pendant groups were synthesized via ROMP of norbornene derivatives, as shown in Scheme 1, and random copolymers were also prepared by the same procedure except that both comonomers were added together.
Note that the aggregation numbers for the micelles of the block copolymer are also larger (Table 2).
The CA-PEI copolymer was also characterized by X-ray diffraction and differential scanning calorimetry.
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