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Traditional exclusion of pregnant women from clinical trials has led to limited data on safety and efficacy of artemisinin based combinations considered for general deployment especially in Africa.
The results obtained appear to be inferior to other cisplatin based combinations.
However, before 2001, there were no published clinical trials of epirubicin-vinorelbine based combinations for neoadjuvant treatment in LABC.
However, some trials – mainly those using platinum based combinations – have shown an increase in response rate (RR) and time to progression (TTP) (Table 1).
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Regimens such as cisplatin or carboplatin combined with paclitaxel, vinorelbine, gemcitabine, docetaxel or irinotecan are among the platinum-based combinations currently used in clinical practice.
Design solutions include mostly relation-based combinations.
The item Value serves as a numeric identifier of these various unique, decile-based combinations.
But if resistance spreads, there are no new drugs to take the place of artemisinin-based combinations and no immediate prospects under development.
Published data from experiments evaluating these and other vancomycin-based combinations, both in vitro and in animal models of infection, often yield inconsistent results, however.
Artemesinin-based combinations are now standard treatment, but resistance is emerging in parts of Southeast Asia, according to the Centers for Disease Control and Prevention.
Artemisinin-based combinations turned out to be fast-acting and seemed to slow transmission of the disease, said Dr. John MacArthur, an infectious disease expert with the United States Agency for International Development in Bangkok.
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