In order to formally describe the template based approach, we use the basic definition of the workflow given in (Eq. 1).
Next, our analysis did not utilize an anchor-based approach, which is often considered more desirable than the distribution-based approaches we used for MCID estimation [ 9, 14].
The individual-based approaches we used here revealed that most of the harbour porpoise range in the central and eastern North Atlantic behaves as a 'continuous' population that widely extends over thousands of kilometres from the French coasts of the Bay of Biscay northwards to the arctic waters of Norway and Iceland, with significant isolation by distance.
The evidence based approach we have used for CONSORT also served as a model for development of other reporting guidelines, such as for reporting systematic reviews and meta-analyses of studies evaluating interventions, 16 diagnostic studies, 17 and observational studies.
After the predicted proteins were classified based on these different approaches, we use several keywords (e.g., symbiosis, pathology, intracellular survival, toxicity, and antibiotic production) to cluster the candidates with similar functions.
We have classified them into three categories (direct-effect QTLs, relQTLs, and epiQTLs) based on the approach we used for their discovery.
Sampling based approaches are used to carry out uncertainty and sensitivity/importance analysis.
Both distributional based and anchor based approaches were used for deriving estimates.
For discovering dysregulated miRNAs, multiple biostatistical or information theory based approaches are used.
A combination of phylogenomic and protein signature based approaches was used to characterize the major clades of cyanobacteria.
Based on the iterative approach we used to calculate this mean and standard deviation, we defined a WS outbreak at these GBR locations to occur when disease counts reached or exceeded 50 cases per 1500 m2; i.e., when the number of WS cases was greater than the mean of the annual maxima plus one SD.
