The MSAT-based approach used here has potential for broad applicability as a cost effective tool toward determining admixture proportions.
This is due to the correlation-based approach used here, as the process of detecting the optic flow is invariant to luminance contrast.
At a 55% CMT, we find that about 20% of the RPGs would differ from the current set if a purely genus-based approach were taken rather than the sequence-based approach used here (data not shown).
From the perspective of the current study, the results indicate that the HMMer-based approach used here is conservative but accurate, as no incorrect assignments were made in our control screen of T. brucei.
The BLAST-based approach used here is currently limited by the uneven representation of major taxonomic groups in the NCBI database, including the phylum Cnidaria.
The pathway-based approach used here may be more powerful to identify associated SNP than a GWAS methodology relying on the large number of associations detected by whole-genome studies.
In contrast to the model-based approach used here, others have used model-free approaches of regional homogeneity (He et al., 2007) or independent component analysis (Greicius et al., 2004; Gili et al., 2011).
The relative frequency p(x), called the D-value in the case of the topology-based approach used here, is then computed independently for each ontology and given by (4) p (x ) = f (x ) f (r ), where f(r) is the frequency (count) of the root term in the ontology under consideration.
The PWWP-domain based tree approach used here segregated the proteins into the same two subgroups established earlier by the relatedness of their SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domains [ 54, 55].
Future studies based on the approach used here should be able to determine whether such coding is mostly in head- or body-centered coordinates.
The availability of parasite lines expressing individual tagged PKs for the almost entire P. falciparum kinome [ 46] now allows implementation of a kinome-wide investigation of kinase function based on the interactomics approach used here for PfCK2.
