Hence, a genomic convergence or systems biology based approach that integrates the information from GWA studies, gene expression and proteomics may facilitate the identification of key pathways that are globally involved in the pathogenesis of the disease and/or interactive factors acting at different levels of disease-gene expression [47].
Recently, an experimentally based approach that integrates crystallographic information of C2H2 zinc finger DNA complexes with binding data from 11 mutants, 7 from EGR finger I, was used to define an improved interaction code (no optimization).
This model was based on SMART approach that integrates the SHIPP methodology and rational theory.
This paper discusses life time prediction of wire bond structure in a power electronic module based on computational approach that integrates methods for high fidelity analysis, reduced order modelling, and life time prediction using reduced order model.
It is based on an evolutionary computation approach that integrates genetic algorithm and genetic programming operators.
Somatic single nucleotide variants (SNVs) were called from pileup files using SNooPer, an in-house variant caller that is based on a machine learning approach that integrates tumoral and normal data and that was specifically trained for optimal identification of somatic mutations in our low-depth SOLiD sequencing data (manuscript submitted and software available upon request).
Based on a new genetic algorithm approach, that integrates flux balance analysis, chemiosmotic theory, and physiological data, the proton translocation stoichiometry for a number of enzymes and maintenance parameters under aerobic chemolithoautotrophic conditions using three different electron donors were estimated.
Based on a workshop of the WHO/IPCS, the framework specifies a four-tiered iterative approach that integrates hazard and exposure assessments for risk-based decision making.
We also seek an approach that integrates inferences across different and diverse kinds of data that can tie together inference based on epidemiology, animal testing, and mode-of-action and pharmacokinetic data.
