One of the simple techniques in the dictionary-based approach is based on bootstrapping using a small set of seed opinion words and an online dictionary, e.g., WordNet.
This stress-based approach is based on the premise that mean stress directly affects the fatigue strength coefficient σ′f, of the Basquin stress life relation.
On the other hand, a ligand-based approach is based on the knowledge of hits found with high-throughput screening, virtual screening, or other combinatorial techniques.
This elegant, science-based approach is based on three in vitro parameters representing a combination of drug substance physicochemical and physiological properties with respect to oral administration; specifically a dose number, dissolution number, and absorption number.
A structure-based approach is based on the observation that most drugs bind to a clearly defined macromolecular target, which is complementary in terms of three dimensional structure and pharmacophoric chemical groups.
Our network-based approach is based on the hypothesis that cellular networks are modular, and consist of inter-connected proteins responsible for specific cellular functions [12], [13].
The gene-based approach is based on the idea that nonsynonymous substitutions may influence the fitness of an individual or population.
The hybridization-based approach is based on multi-dimensional pools of molecular markers or probes hybridizing with high-density BAC library screening membranes to identify the BAC clones associated with specific nucleotide sequences or genes.
