In the cohort, exacerbations will be identified by means of an event based approach, whereas in the RCT exacerbations will be identified by means of an event based approach (health care contact) and symptom based approach (clear increase of respiratory symptoms).
Symptoms questionnaires and symptom based criteria such as "Early and Long Lasting (ELL -symptoms" havELL -symptomsnostic properties [ 2, 16].
Analysis for the clinical symptoms stream involves describing the frequency and severity of symptoms based on the clinical symptom instrument.
The patients were stratified by the clinicians into four groups based on the severity of their symptoms based on their clinic experience: 'no current symptoms' (n = 34), 'mild symptoms' (n = 40), 'moderate symptoms' (n = 42), and 'severe symptoms' (n = 30).
All patients had a clinical diagnosis based on signs and symptoms and biochemical diagnosis based on 17-hydroxyprogesterone levels.
The definition of asthma remains arbitrary and mainly symptom based.
Criteria based diagnoses are more accurate than symptom based diagnoses.
The instruments may be symptom based, satisfaction based or organ system specific.
In the absence of the advent of a superior novel antipsychotic to clozapine, a symptom based approach based on the best available research in other clinical disorders may provide some guidance in adjunct therapy.
*Against clinicians diagnosis based on signs and symptoms alone.
