Therefore, extensive population based studies and clinical studies are required to characterize the vast SNP data and for the verification of the findings of the current study.
The prevalence of peripheral vascular disease in population-based and clinical studies varies (5.1 38.9 % in diabetic patients, 2.6 12.2 % in nondiabetic patients) [8, 9, 10, 11].
Moreover, recent population-based and clinical studies have shown that the chronic pain is not self-limiting, despite treatment at specialized clinics [ 18, 34, 40, 45].
The magnitude of the associations observed concords with that reported in previous population-based and clinical studies [ 25- 33, 35, 36, 38, 39].
Earlier population-based and clinical studies have shown that a decrease of HRV is present both in anxiety and depression [ 52- 54], although the correlation of HRV and SOC-score is not previously shown.
As in previous population-based and clinical studies (Ruder et al, 1989; Northridge et al, 1997; Early Breast Cancer Trialists Collaborative Groupp, 1998; Li et al, 2003), tumour morphology and hormone receptor status are important predictors of breast cancer survival.
Among these, non-Hodgkin lymphomas and multifocal leukoencephalopathy were associated to more than 3-fold higher ORs, similarly to what reported in other population-based and clinical studies conducted in several high-income countries [ 20, 23].
