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This study evaluates the effects of spatial smoothing on inter-subject correlation (ISC) analysis for FMRI data using the traditional model based analysis as a reference.

This is critical for PWM based analysis, as a considerable fraction of TFBSs from PWM searching is non-functional.

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This problem occurs even in solely, sequence based analysis as well [ 40].

The silencing efficacy was determined using image based analysis as follows.

An important practical implication of this study is that one should remove all rRNA sequences from a random shotgun dataset before performing an NCBI-NR banalysislysis, as they will lead to false positive assignments.

The cellular immune response against gp160BF was mapped by a matrix peptide based analysis as described in Figure 3. Thus, after the identification of the peptides targeted doing a matrix ELISPOT repeated in two different experiments (data not shown), the specific responses employing the individual peptides as the antigenic stimulus were confirmed (Fig. 4B).

Evidence for non-neutral evolution was assessed by comparing the rate of non-synonymous substitutions with the rate of synonymous substitutions (dN/dS  = ω) using a likelihood-ratio-test based analysis as implemented in the SLR software package ("sitewise likelihood-ratio"; [30]).

The combined effect of incomplete retrieval by the data base searches on the one hand and responder bias in the survey on the other hand resulted in a significantly higher publication rate for the survey based analysis as compared to the data base search (64% vs. 47%).

Additionally, we used the LRT based analysis as implemented in the SLR (Sitewise Likelihood-Ratio) software package [ 45].

The model based analysis showed as well an association between the significant shorter lengths of stay in French parts of Switzerland and the respective higher hospitalization rates.

We performed the seed based analysis of the DBM maps, with SN as a seed region.

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