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Signaling downstream from activating receptors commonly involves the phosphorylation of the immunoreceptor-tyrosine based activation motifs (ITAMs).
The activation of the collagen mechanism is specified using a new fiber strain based activation criterion.
The γ-chain is responsible for intracellular signalling via its immunoreceptor tyrosine based activation motif (ITAM).
Although insects do not possess an adaptive immune system and rely solely on their innate immune system, they utilize ITAMs (immunoreceptor tyrosine based activation motifs).
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DAP12 is able to stimulate cytotoxic activity as it contains an immunoreceptor tyrosine-based activation motif and is the mode in which activating KIRs have an effect.
Although this signaling is activating, it does not utilize an immunoreceptor tyrosine-based activation motif (ITAM).
468 CRC cases were first scored for RAS pathway activity with an 18-gene RAS pathway gene expression-based activation score.
An immunoreceptor tyrosine-based activation motif (ITAM) in the LMP2A N-terminus is constitutively phosphorylated and activates the protein tyrosine kinase (PTK) Syk [ 3].
Vertebrate members also carry an immunoreceptor tyrosine-based activation motif.
Isakov, N. et al. ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.
Isakov, N. Immunoreceptor tyrosine-based activation motif (ITAM), a unique module linking antigen and Fc receptors to their signaling cascades.
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