Sentence examples for base to activate the from inspiring English sources

The second hydroxyl group on the 4 position of piperidine contacts Asp81, the key active site residue that acts as a base to activate the 1-OH of sphingosine, via a hydrogen bond.

In the hydrolysis step, the H300 side chain acted as a potential general base to activate the hydrolytic water molecule for nucleophilic attack on the alkyl enzyme intermediate.

The best results were obtained by using complexes with a nucleophilic counter-ion that was capable of acting as a Lewis base to activate the trimethylsilyl cyanide.

Similarly, Cys917 (Tyr463 in XcOGT) has been proposed to be the catalytic base to activate the peptide substrate, but is not in proximity to the GlcNAc anomeric carbon in the UDP- S-GlcNAc complex.

This Tyr387 is conserved amongst XcOGT and hOGT (Fig.  2a; Clarke et al. 2008) and is in close proximity to Lys388, which could prime the tyrosine to act as a base to activate the acceptor substrate.

The authors observed that the monosodium binaphtholate salt was not an effective catalyst and speculated that the role of disodium binaphtholate might be as a Lewis base to activate the TMSCF3 and form the hexavalent intermediate 271 (Scheme 100).

As with all campaigns, success requires the delicate balance of energizing the base to activate donors and volunteers while appealing to the middle, who ultimately will decide the electoral outcome.

On the basis of these observations, the authors speculated that the hydride ion might serve as the Lewis base to activate TMSCF3 (Scheme 101).

Subsequently, Glu-166 acts as a general base to activate a water molecule for deacylation of the enzyme.

This model is consistent with the mechanism of many other zinc enzymes that use an aspartic acid as a general base to activate a water or hydroxide ion.

This may serve in the non-redox role of Asc as the base catalyst to activate the reaction but not as the reductant to reduce oxygen.