Sentence examples for base substitutions within the from inspiring English sources
It was later shown that base substitutions within the "A·C" wobble base pair disrupt Prp24 protein binding and reduce stability of the U4/U6 complex [46].
To precisely define the −KTS-specific response elements in the GC-rich region of the ENT4 promoter, we introduced base substitutions within the three potential EWS/WT1 −KTS) binding sites of the P2 promoter (Fig. 2D).
Mutated binding site constructs contained 4 base substitutions within the seed site predicted to disrupt miRNA binding.
In-silico detection of polyadenylation sites may also prove useful for identifying non-templated nucleotide addition prior to polyadenylation [ 32], as well as base substitutions within the polyA tails that are not due to sequencing errors but, in fact, might have biological meaning.
A set of 39 CR1s from subfamily I contained octomers (TTCTGTGA) that had one or two base substitutions within this region.
The base substitution within the restriction site would result in the presence/absence of the restriction site of BsrGI in the amplified product.
The base substitution within the restriction site would result in presence/absence of the restriction site in the amplified product to generate a polymorphism.
DNA sequencing confirmed the presence of a G to T base substitution within the Hae III site spanning codons 249 and 250 of the p53 gene that results in replacement of arginine (wild-type) by methionine at residue 249.
To further investigate the ATAF2 binding sequence a series of six two-base substitutions within the identified 30-bp DNA fragment were created and tested for their effects on ATAF2 binding.
The results support the notion that both base substitutions within genes and gene duplication are associated with gene expression breadth and that the nature of duplication (WGD or SSD) differs substantially depending on the germ-layer origin of the tissue.
