Sentence examples for base substitutions were identified from inspiring English sources
A total of 183,916 somatically acquired base substitutions were identified (see Table S1B for hyperlinks).
Sequence changes (e.g. indels, base substitutions) were identified by finding base changes between each tumor and its matching normal sequences.
A total of 14 single base substitutions were identified at different positions, the number of substitutions in TaBiP1, TaBiP2, and TaBiP3 being 8, 5, and 4, respectively (Table 2).
Four base substitutions were identified in total (listed in Table 2): samples 21 and 29 harboured mutations at codons 249 and 214, respectively, while sample 7 contained two mutations, one at codon 245 and a second silent mutation at codon 247.
A total of 14 single base substitutions were identified at different positions, and of these, six were non-synonymous mutations, which did not appear to alter the function of TaBiP, although the associated structural changes have led to different classifications in cereal crops.
Second, nucleotide substitutions were identified if the majority of bases in the reads differ from the reference genome with read depth of 5 or more.
This base substitution is identified in 50% of HCC cases from areas with AFB1 exposure, but not in HCC without AFB1 exposure.
A single nucleotide substitution was identified (C1690→T1690) that resulted in an amino acid substitution from Pro509 to Leu509 (Fig. 5A).
Kataegis substitutions were identified based on their intermutation distances (regardless of sequence context) and excluded from the other substitutions.
Dinucleotide substitutions were identified when two substitutions were present in consecutive bases on the same chromosome (sequence context was ignored).
