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In recent years, the rapid progress of high-throughput technologies has led to the unveiling of epigenetic landscapes at genome-wide scale (epigenomes) exemplified by the deciphering of the full methylomes, at single base resolution, of the model plant Arabidopsis and crop plants such as rice and tomato.
3) The full power of single base resolution of the RPF analysis is not harnessed to de-convolute the effects of stress and ISRIB on the translation of uORFs in ATF4 and ATF5.
We have included mean normalized counts for all transcripts in all conditions tested in Figure 1 figure supplement 9. 3) The full power of single base resolution of the RPF analysis is not harnessed to de-convolute the effects of stress and ISRIB on the translation of uORFs in ATF4 and ATF5.
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In parallel, location-specific consensus motifs in promoter sequences were discovered by virtue of TSSs identification with one-base resolution of the method.
However, a single base resolution of methylation profiling of the Xi and Xa in different stages of X chromosome inactivation is necessary to determine the factors that rule the methylation status of a given X-linked CpG site.
Often we base resolutions on the recommendations of epidemiologists, which are "probably at too high a standard," says Michelle Segar, a psychologist at the University of Michigan.
Furthermore, it fully exploits the base-resolution of the data to enable simultaneous detection of methylation changes in even contrasting size ranges, such as focal hypermethylation and global hypomethylation in cancer methylomes.
The base spatial resolution of the sliding windows was set to 64 × 64 pixel with 67%% spatial overlap for localization which builds on a non-maxima suppression procedure.
The base pair resolution of the aggregation can be specified by the number of bins (narrower bins give more data points and therefore finer granularity).
10.7554/eLife.09225.005 Figure 3. High-resolution X-ChIP-seq provides base-pair resolution of the minimal CTCF sequence motif.
HMM-based segmentation represents another useful approach that fully exploits the base-resolution of WGBS data [ 5].
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