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Howard was especially curious about how variations of base pairs within the two genes interacted with each other to impact asthma.
Through further regulation of the number of aptamer-involved base pairs within the duplex we can tune not only the signal increase but also the response rate of these synergically stabilized duplex probes to achieve optimal sensor performance.
However, owing to the dynamical motions of the base pairs within the molecular stack, as well as sequence-dependent inhomogeneities in energetics and base base couplings, DNA charge transport differs considerably from that in solid state π-stacked materials.
These strains are designated as TcdA-negative though, regarding serogroup F-strains, mere lacking 1800 base pairs within the repetitive regions [29], [30].
For example, although our nested PCR technique amplified a hyper-variable region of the 16S rRNA Helicobacter genome which equated to an estimated average evolutionary diversity of 14 base pairs within the 9 species identified [34], it is not possible to be certain of the Helicobacter species without additional genotypic or phenotypic characterisation [35].
When both number of matched and the nature of mismatched base pairs within the proximal-8 region are taken into account, the number of subclasses for the classes 7, 6 and 5 were found to be 116, 528 and 672, respectively.
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Crispr-Cas9 is able to edit genes at the smallest resolution – down to a single base pair within the sequence of the 3bn bases that make up the human genome.
Although it is not possible to further characterize structural details of this extra mass, our data from the high salt treated sample reveals, at least partially, the location of the precursor sequences of the 17S rRNA, confirming the presence of complementary base pairing within the 5′ end, as well as between the 5′ and 3′ ends in the 17S rRNA precursor.
Zhang et al. created a polyvalent scaffold using polyadenine sequences to prevent nonspecific and undesired base pairing within the backbone.
Mutations which destroy base pairing within the stem are therefore deleterious [ 42] and will be eliminated or kept in low frequency.
MicroRNAs (miRNAs) are short, noncoding RNAs that generally base pair within the 3′ untranslated (3′UTR) region of target mRNAs, causing translational inhibition and/or mRNA degradation.
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