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We have fabricated a DNA-based nanofiber created by self-assembly of guanine quadruplex (Hoogsteen base pairing) and double-stranded DNA (Watson-Crick base pairing).
The weak base-pairing behavior of orotamide 6 with adenine (Δp Ka ≈ 3) versus the stronger base pairing of 5 with thymine (Δp Ka ≈ 5) is consonant with the Δp Ka/base-pairing strength correlation (Table 1).
Base pairing between U2 snRNA and the branchpoint sequence (BPS) is essential for pre-mRNA splicing.
Each successive ribonucleotide is directed by the complementary base pairing rules of DNA.
Topal, M.D. & Fresco, J.R. Complementary base pairing and the origin of substitution mutations.
Baytekin, H. T. & Akkaya, E. U. A molecular NAND gate based on Watson−Crick base pairing.
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A high normalized SHAPE reactivity indicates high flexibility and thus low probability of base-pairing, while low reactivity indicates high likelihood of base-pairing [ 40, 41].
COMRADES detected base-pairing.
"Unusual Base-Pairing Interactions in Monomer Template Complexes". ACS Central Science 2 (12): 916-926.
COMRADES scores represent the number of chimeric reads supporting each base-pairing along the viral RNA.
b, Precision and sensitivity of ribosomal RNA base-pairing detection by COMRADES.
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