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Furthermore, no major differences were found in the nature of base pair substitutions between ATLD patients (753 mutations) and normal controls (750 mutations), except that there was a small, albeit significant, increase of A to C transversions in the ATLD patients (8.8 vs. 5.3% in controls, χ2 test, p<0.01).
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Our results suggest that many features of the distribution of abundance and length of microsatellites can be explained by this simple model, which incorporates a competition between slippage events and base pair substitutions, with no need to invoke selection or constraints on the lengths.
In either case, light-induced damage can result in DNA base pair substitutions, large and small deletions, inversions or somatic recombinations between non homologous chromosomes [ 30].
Simian virus 40 (SV40) mutant 5002 carries base pair substitutions of C-5109----T C-5109----T C-5109----T C-5109----T C-5109----T C-5109----T
Of all SNPs, we found transitions to be over-represented: 64 74 % of all single base pair substitutions were transitions.
Single base pair substitutions were randomly distributed over the gene.
In 613 base pairs, 15 single base pair substitutions or indels were found plus 12 base pair differences or indels that involved more than one consecutive nucleotide.
Additionally, cross-reactivity might result from (rare) base pair substitutions that are not covered by the used assays.
The frequency of base pair substitutions was 0.8-1.0 0.8-1.0
This corrected indels and base pair substitutions within initial assemblies.
However, base pair substitutions in transcription, or single base pair misinterpretations in translation, will follow the same pattern.
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