Sentence examples for base pair level of from inspiring English sources

The small RRL size allowed for PCR-based confirmation and characterization of the SV at the base pair level of acquired deletions and small insertions with minimal sequencing efforts.

DOC [ 19] algorithms detect regions with absent (deletion) or significantly elevated (duplication) coverage, but are not able to determine the exact insertion location on the base pair level of the duplicated sequence.

Finally, we showed that little sequencing effort on a reduced representation of a genome is sufficient for the detection and base pair level annotation of a variety of SVs in a sequenced genome.

However, the base pair level resolution of this sequencing-based method generates volumes of data that are difficult to process and analyze on desktop computers.

Designing PCR primers based upon the PacBio results allowed for Sanger confirmation of the junctions and base pair level resolution of the three novel (2 to 2) junctions.

Validation of the novel variants was conducted and base pair level resolution of breakpoints was achieved by performing Sanger sequencing.

Base pair level coverage of the region 2 kb upstream, to 120 kb downstream, of each transcript's TSS was calculated for each sample.

The precision and accuracy of the experimental curves were improved to near base pair level by cross-correlation of regions immediately before the Gal4DBD disruption and after the nucleosome disruption, using methods as previously described (Hall et al., 2009; Li and Wang, 2012).

On a base pair level, this translates to 2.2% of M. truncatula and 1.7% of soybean genomic sequence.

As knowledge regarding precise genetic abnormalities underlying a variety of dermatological conditions continues to emerge, the ability to introduce corresponding alterations in endogenous gene loci in mice, often at a single base pair level, has become essential for detailed studies of these genetic diseases.

Mutations in a genome consist of not only base pair level changes but also events that alter the chromosome structure, such as inversions, duplications or deletions [ 1].