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This model proposes that genetic coding arose de novo from complementary base pair interactions between tRNAs and single-stranded RNAs present in the immediate environment.
Furthermore, other similar reports have shown that there are no drastic differences in nearest neighbor base pair interactions between PS-DNA and APS-DNA having mixed AT/GC composition.
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Activated RISC then binds to complementary transcript by base pairing interactions between the siRNA antisense strand and the mRNA.
They represent cross-serial base pairing interactions between RNA nucleotides that are functionally important in tRNAs, RNaseP [ 2], telomerase RNA [ 3], and ribosomal RNAs [ 4].
These data serve as a nice counterpoint to a recent paper in Cell, reporting that base pairing interactions between flanking introns can contribute to exon circle formation.
This difference is readily explained by the presence of two Watson Crick base pairing interactions between C3 G6 and C4 G5 that stabilize the strand slippage in state IV, which prevent its loss on the 10 ns time scale.
RNA-guided nucleases (RGNs) provide sequence-specific gene regulation through base-pairing interactions between a small RNA guide and target RNA or DNA.
Since there are various base-pairing interactions between miRNAs and their target RNAs, such interactions may contribute in the generation of various and complex gene regulatory events.
The program RNAhybrid [ 17] was used to identify potential base-pair interactions between Spot 42 and the 5' UTR region of the pirin mRNA (VSAL_I1200).
The short structural branchpoint distance for the RPS17B intron results from two base-pair interactions: between the first intron base (G) and the third base of the branchpoint sequence (C); and between the second base in the intron (U) and the second base of the branchpoint sequence (A) (see Figure 4).
In the suboptimal prediction that has d s = 6 there is no base-pairing interactions between the donor and branchpoint sequences.
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