Sentence examples for base orotate which is from inspiring English sources
Pyrimidines, on the other hand, are synthesized from the base orotate, which is formed from glutamine and aspartate.
One of the most interesting steps of this pathway is the conversion of dihydroorotate to orotate, which is carried out by enzymes classified into two families of dihydroorotate group dehydrogenases (DHODs), according to the terminal electron acceptor and relationships at the sequence level [ 51].
My base, which is a big base; I think my base is 45percentt".
Potassium oxonate is a reversible competitive inhibitor of orotate phosphoribosyltransferase, which is an enzyme for 5-FU phosphoribosylation in the gastrointestinal mucosa.
Which is based on my own story.
Its major target is supposed to be dihydro-orotate-dehydrogenase (DHODH) [ 10], which is a key enzyme in de novo pyrimidine synthesis.
An important target for antimalarial chemotherapy is the enzyme dihydroorotate dehydrogenase from Plasmodium falciparum (PfDHODH), which is responsible for the conversion of dihydroorotate to orotate in the de novo pyrimidine biosynthetic pathway.
After dissociation of orotate from the enzyme, FMNH2 is regenerated by a ubiquinone molecule, which is recruited from the inner mitochondrial membrane.
The orotate accepts a pentose phosphate moiety [73] from 5-phosphoribose 1-pyrophosphate (PRPP); PRPP, which is formed from ribose 5-phosphate and ATP, also initiates the pathways for biosynthesis of purine nucleotides (Figure 11) and of histidine (Figure 10).
