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Based on the current understanding of the effects at the cellular level of OXPHOS system defects, various new small molecules able to counteract such consequences are in preclinical development and some have reached the clinical development phase12,35,36.
However, based on the current understanding of CB1 ligand binding, existing bivalent ligands are too short to bind both receptors simultaneously.
Based on the current understanding of TLR9 recognition of CpG ODN, we have tried to design a series of CpG ODNs that display double stem-loops when being analyzed for their secondary structures using 'mfold web server'.
While rational design based on the current understanding of gene delivery process has produced various cationic polymers with improved overall transfection, high-throughput parallel synthesis of libraries of cationic polymers seems a more effective strategy to screen out efficacious polymers.
The process is based on the current understanding of the technical capabilities of the imaging modalities examined.
The genesis of diamond-nanotube composite from candle wax seeds can be understood qualitatively through a mechanism (Figure 4) based on the current understanding of the CVD of diamond and CNTs and the decomposition of candle wax.
Based on the current understanding of cells, the function of a cell is primarily regulated by the genes that are being actively expressed (i.e., when RNA is being generated from selected genes and these RNA molecules are then translated into functionally active proteins).
Genetic interaction with sqh but not Drok or zip/MyoII was unexpected based on the current understanding of the wing PCP pathway (Fig. 5A).
The general interpretation, based on the current understanding of gene regulation, is that genes under greater regulatory control require more regulatory information, resulting in a longer upstream intergenic sequence [4], [6].
Note: this is based on the current understanding of entrainment physiology.
In this minireview we summarize the role of the emerging urinary biomarkers of obstructive nephropathy based on the current understanding of the pathophysiology of renal injury.
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