Sentence examples for base of the substrate from inspiring English sources

This enzyme binds the purine base of the substrate between the aromatic side-chains of Trp83 and Trp260.

The process involves a self-protonation mechanism whereby the two-electron reduction product, a cyclic derivative, is formed together with the conjugate base of the substrate, as a consequence of proton transfer from the substrate itself to the basic intermediates.

The adenine ring is nearly parallel to the "seat" of the structure while the nicotinamide portion faces backwards, pointing to the base of the substrate binding cavity [ 20].

Comparison of the crystal structures (AfChiA1 PDB 2XVP [23] and AfChiB1 PDB 1W9P [29]) of both chitinase subclasses in A. fumigatus reveals a deep pocket unique to plant-type chitinases in the base of the substrate binding groove.

The residues located in the NRM stabilize the base of the substrate nucleotide triphosphate via water-mediated and/or direct hydrogen bonds with their side chain atoms [ 51– 51].

Based on the substrate of cellobiose, the activities of β-glucosidases produced by F. proliferatum growing in corn stover + wheat bran based medium and glucose based medium were 426 U/ml and 187 U/ml, respectively.

This diversity, combined with the large number of potentially acetylable lysines on histones, suggested the existence of a specific regulatory mechanism based on the substrate specificity of HATs.

The enzymatic method was based on the substrate of α-D-mannosidase.

Based on the substrate specificities of the defined nitrilases, this cluster was designated as the predicted mandelonitrile hydrolase subgroup.

Designing inhibitors based on the substrate envelope of HIV protease is a recent strategy for developing HIV protease inhibitors.

Among KLK3 selected sites, the D207S replacement that occurred shortly after the duplication is located at the base of the substrate-biding pocket (fig. 2 B).