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Because energy metabolism is being recognized as a/the critical pathway regulating the immortalization-to-senescence transition, metformin-based therapies based on the induction of senescence would prevent the generation of CSCs.
Therefore, we estimated the activation of mp53 based on the induction of WAF1 which is one of downstream factors regulated by p53.
b The bioactivity assay of proteins based on the induction of hypersensitive response (HR) in tobacco leaves.
Several considerations also impact the interpretation of predictions based on the induction of transcription factors.
Our inability to fully understand the pathogenesis and find curative treatment for FSGS may be due to the fact that almost all of the animal models used are based on the induction of secondary forms of FSGS.
Of note, OMVs can be designed to deliver their cargo in an intracellular fashion, allowing the potential induction of cellular responses instead of the more traditional approach of vaccine, which is mostly based on the induction of antibody responses.
Therefore, the cytotoxic mechanism of AgNPs is predominantly based on the induction of reactive oxygen species (ROS).
Most therapeutic vaccines are usually divided into two groups according to their mode of action on immunity, based on the induction of either a Immoral response (antibodies) or a cellular response, mostly cytotoxic T lymphocytes (CTLs).
The assay is based on the induction of expression of a firefly luciferase reporter by a chimeric transcription factor in which the viral protease and cleavage sites are inserted between the GAL4 binding domain and the VP16 activation domain.
Activation of NF-κB is a common pathway based on the induction of phosphorylation, which mediates proteasomal degradation of IκB [ 56].
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CEO of Professional Science Editing for Scientists @ prosciediting.com