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At the base of the dock was a black Lincoln Town Car, its windows a sheen in the security light.
Unable to whip out his measuring tape and get the dimensions of the loading dock, Petit brilliantly threw himself against the base of the dock, the dust from which imprinted on his shirt, allowing him to get the precise data he needed.
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Each day, the amount of labor hours needed based on the dock traffic expected is transmitted to the union's hiring hall.
Firstly design techniques based on the docking of small numbers of ligands into receptor models are discussed.
Based on the docking scores of a series of bisanthrapyrazoles with different numbers of methylene linkers (n) that were docked into an X-ray structure of double-stranded DNA, five bisanthrapyrazoles (n = 1 5) were selected for synthesis and physical and biological evaluation.
Here, this collection was done either by gathering all the poses in a pool and rescoring them with the programs or, still better, by the use of USC based on the docking results.
A series of PI3K-beta selective inhibitors, imidazo[1,2-a]-pyrimidin-5(1H -ones, has been rationally designed based on the docking model of the more potent R enantiomer of TGX-221H -onesified by a chasal separation, in a PI3K-been homology model.
The "initial filter" was built based on the docking results of boronic acid derivatives validated as reversible inhibitors of MP by our previous studies.
Based on the docking modes of the most potent hit compound, a series of derivatives are synthesized, characterized and biological assayed on the PLK1, EEF2K as well as breast cancer cell proliferation models.
Based on the docking analysis of compounds 5 21, we have also evaluated the docking of two potent β-aminoxy-N- methylsulfonyl) propionamides (compounds 24 and 26) to TTR hormone binding pocket using Goldscore algorithm.
Finally, the 174 hits were further validated by using a new pharmacophore model HypoB built based on the docking pose of BQR685, and 95 compounds passed the last filter.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com