Sentence examples for base of the crypts from inspiring English sources

The anoxic lumen in part establishes the oxygen gradient of the intestinal epithelium, as cells directly adjacent to the lumen are hypoxic relative to the cells that are close to the base of the crypts [2].

In control mice, Axin2 is expressed at the base of the crypts (Fig. 6C).

Nevertheless, no positive staining for the FcεRI γ-chain was observed in Paneth cells at the base of the crypts (data not shown).

In the small intestine, epithelial cells transit through differentiation steps initiated in progenitor cells, which reside adjacent to Paneth cells at the base of the crypts [15].

However, A-type lamin expression was high in approximately five to ten cells at the base of the crypts (Figure 1A, arrows).

More recently, expression of the Wnt response element Lgr5 has been shown to define colonic stem cells and has been used to confirm that the stem cells occupy a niche at the base of the crypts [27].

Intestinal stem cells (ISCs) are located at the base of the crypt and are responsible for repopulating the cycling mucosa up to the villus tip.

Key factors localized at the base of the crypt are necessary to promote ISC self-renewal and proliferation, to ultimately provide a constant stream of differentiated cells to maintain the epithelial barrier.

This resulted in an increase in the overall size of the crypts, as determined by measuring crypt depth from the base of the crypt to the crypt-villus junction (Fig. 4 and 5A).

Using this approach, the origin of migration and, by extrapolation, the stem cell niche has been predicted to reside at the base of the crypt [35].

The IELs per 100 nucleated enterocytes (100NE) were counted at 24 randomly selected sites between the villus tip to the base of the crypt in each biopsy.