Sentence examples for base of the crypt from inspiring English sources
Intestinal stem cells (ISCs) are located at the base of the crypt and are responsible for repopulating the cycling mucosa up to the villus tip.
Key factors localized at the base of the crypt are necessary to promote ISC self-renewal and proliferation, to ultimately provide a constant stream of differentiated cells to maintain the epithelial barrier.
Following exposure to ionizing radiation, cells located at the base of the crypt undergo rapid apoptosis, or stop dividing temporarily or permanently.
The IELs per 100 nucleated enterocytes (100NE) were counted at 24 randomly selected sites between the villus tip to the base of the crypt in each biopsy.
Using this approach, the origin of migration and, by extrapolation, the stem cell niche has been predicted to reside at the base of the crypt [35].
This resulted in an increase in the overall size of the crypts, as determined by measuring crypt depth from the base of the crypt to the crypt-villus junction (Fig. 4 and 5A).
The anoxic lumen in part establishes the oxygen gradient of the intestinal epithelium, as cells directly adjacent to the lumen are hypoxic relative to the cells that are close to the base of the crypts [2].
In induced Cre+Cdh1fl/fl mice staining of the Wnt target gene EphB3 appeared unchanged at the base of the crypts compared to controls (Fig. 6A and not shown).
Nevertheless, no positive staining for the FcεRI γ-chain was observed in Paneth cells at the base of the crypts (data not shown).
In the small intestine, epithelial cells transit through differentiation steps initiated in progenitor cells, which reside adjacent to Paneth cells at the base of the crypts [15].
