Sentence examples for base mutations within the from inspiring English sources
Our lab has shown that single-stranded oligonucleotides (ODN) can be used to repair genes with single base mutations within the context of the native chromosome.
The number of sequences in the distinct homologous families ranged from 6 110 (Table 1) with few base mutations within a family.
By itself, such a mechanism is incapable of explaining similarities between complementary-base mutations within each of these two classes.
To determine if the GLS is required for normal gurken gene function, we created a rescue construct, called grkGLSmut, that is identical to grkwt, except for the inclusion of 12 single-base mutations, all within the GLS.
Three base-pair mutations within the NaCDEI (21 23a and 24 26c) and NaCDEII (45 47t) of NcCEN1 showed substantial decreases in yeast colony formation and high copy numbers of minichromosomes (>70 per cell), indicative of inefficient segregation.
The PG-1 allele is the result of a spontaneous single-base mutation within a AtMYB90 transgene that acts as a dominant-negative 'repressor' of pigment production in tobacco flowers.
In addition, a second construct was created with a 5 base pair mutation within the target seed site (Psi/miR34amut).
Leukocyte adhesion deficiency type 1 (LAD-1) is an autosomal recessive disorder based on point mutations within the β2 integrin, resulting in either its absence on the cell surface or the inability to associate with the corresponding α subunit.
A single-base nonsense mutation within the coding region of an active Arabidopsis AtMYB90 transgene (the PG-1 allele) was found to convert the R2R3-myb gene from a transcriptional activator of plant-wide anthocyanin biosynthesis to a dominant-negative allele that was able to interfere with normal tobacco pigment production within flower petals.
After quality control, sequence error rate was estimated as the percentage of single-base mutations in the rpl32- trnL region within individuals and was found to be approximately 0.13% (see Methods).
We have developed a novel concept for immunogen construction based on introduction of massive mutations within the epitopes targeting antigenically variable pathogens and diseases.
