Sentence examples for base modifications such as from inspiring English sources
In nanopore sequencing devices, electrolytic current signals are sensitive to base modifications, such as 5-methylcytosine (5-mC).
Base modifications, such as DNA methylation, are key components of biological processes such as gene expression, host-pathogen interactions, DNA damage and DNA repair.
These kinetic measurements present characteristic patterns in response to a variety of base modifications such as 5-methylcytosine, 5-hydroxymethylcytosine, 6-methyladenine, 8-oxoguanine, and more.
Additionally, PacBio's sequencing technique provides information that is useful for the direct detection of base modifications, such as methylation.
XPD readily translocates past base modifications such as bulky extrahelical modifications and abasic sites (Rudolf et al, 2010; Figure 6C).
Because PacBio sequencing takes place in real time, kinetic variation interpreted from the light-pulse movie can be analyzed to detect base modifications, such as methylation [6].
Whereas ROS generated by bio-negative doses of UV-B radiation is capable of inducing several major types of DNA lesions such as DNA strand breaks, deletion or insertion of base pairs, pyrimidine dimers, cross-links, and base modification, such as alkylation and oxidation.
Home modifications such as grab bars or wheel-chair ramps.
This phenomenon could not be interpreted by the usual genetic mechanisms, such as a change in the DNA sequence (that is, mutation), but can be explained by reversible epigenetic mechanisms based on chemical modifications, such as DNA methylation.
We then tested the sensitivity to various concentrations of hydrogen peroxide (H2O2), which produces highly reactive hydroxyl radical inducing many DNA modifications, such as release of free bases, single strand breaks, sugar modifications, or AP sites [24].
Certain chromatin modification clusters in H appear to be analogous to ones in IMR90 based on the patterns of modifications, such as the "enhancer-like" state 1 (H) with state 1 (IMR90), and the "promoter-like" state 5 and state 6 (H) with state 2 (IMR90).
