Sentence examples for base modifications in the from inspiring English sources

In addition, it is possible to include specific base modifications in the ODNs in order to prevent their degradation by exonucleases in vivo.

In the different branches of this cluster different SCC mec were introduced, so did repeat deletions, duplication and/or base modifications in the variable region of spa.

Furthermore, in order to target both methylation and hydroxymethylation (or other base modifications) in the same reaction, it is possible to use a cocktail containing several restriction enzymes providing –TA protruding ends.

13 Base modifications in the major groove (5-position for pyrimidines, 7- or 8-position for purines) are more suited for enzymatic incorporation than minor-groove modifications; 14 still the introduction of some substituents in the major groove can be difficult, 15 although this can sometimes be circumvented by the use of long linkers.

Single base-level analysis of 5hmC is now possible [ 45] allowing for a more precise mapping of this base modification in the genome.

Our analysis suggests that base modifications in miRNAs may prevent the maturation of miRNAs, although it is also possible that some base modifications in miRNAs may inhibit or enhance the targeting of miRNAs.

This similarity suggests common base modifications in miRNAs and tRNAs, although the nature of base modifications in miRNAs can only be determined experimentally in the future.

More importantly, this is the first report of the possibility of RNA base modifications in miRNAs with methyl or acetyl groups.

What would be the biological effects of base modifications in miRNAs?

The positions of major substitution sites corresponded with the following known RNA base modifications in tRNAs: N1-methyladenosine (mA), N2-methylguanosine (mG), and N2-N2-methylguanosine (m2G).

The repair rates of oxidative DNA base modifications in V79 cells overexpressing frataxin were significantly higher than in control cells.