Sentence examples for base modification in the from inspiring English sources

Single base-level analysis of 5hmC is now possible [ 45] allowing for a more precise mapping of this base modification in the genome.

In addition, it is possible to include specific base modifications in the ODNs in order to prevent their degradation by exonucleases in vivo.

In the different branches of this cluster different SCC mec were introduced, so did repeat deletions, duplication and/or base modifications in the variable region of spa.

Furthermore, in order to target both methylation and hydroxymethylation (or other base modifications) in the same reaction, it is possible to use a cocktail containing several restriction enzymes providing –TA protruding ends.

13 Base modifications in the major groove (5-position for pyrimidines, 7- or 8-position for purines) are more suited for enzymatic incorporation than minor-groove modifications; 14 still the introduction of some substituents in the major groove can be difficult, 15 although this can sometimes be circumvented by the use of long linkers.

Metal complexes have been extensively studied for their nuclease-like activity using the redox properties of the metal and dioxygen to produce reactive oxygen species to promote DNA cleavage by direct strand scission or base modification in cancer cells (Burrows and Muller 1998).

Base modification in bacterial genomes is performed by two classes of DNA methyltransferases: (i) those associated with restriction-modification systems, and (ii) solitary methyltransferases that do not have a restriction enzyme counterpart.

Our analysis suggests that base modifications in miRNAs may prevent the maturation of miRNAs, although it is also possible that some base modifications in miRNAs may inhibit or enhance the targeting of miRNAs.

This similarity suggests common base modifications in miRNAs and tRNAs, although the nature of base modifications in miRNAs can only be determined experimentally in the future.

More importantly, this is the first report of the possibility of RNA base modifications in miRNAs with methyl or acetyl groups.

What would be the biological effects of base modifications in miRNAs?