Sentence examples for base mismatched from inspiring English sources

Complementary hybridized targets gave over four times higher fluorescent intensities, compared with one base mismatched hybridizations.

This biosensor displayed high specificity, which could discriminate target microRNAs from one base mismatched microRNAs.

This method improved the sensitivity and reached 4 orders of magnitude in detection limit, and showed excellent selectivity to discriminate single base mismatched targets well.

In addition, the existing change presented around 40%% when DNA probe hybridized with full complementary target DNA and presented with only 20 and 5 % upon the introduction of single and second base mismatched DNA.

The ability of our developed biosensor for discriminating the single base mismatched DNA related to a human genetic disease, hereditary tyrosinemia type I, was improved undoubtedly once A12-MB2-A12 was used as capture probe comparing with previous report.

In our experiments, two kinds of adenosine-based molecular beacon probes with twelve adenosines bases at each end (A12-MB1-A12 and A12-MB2-A12), and their complementary target DNA, non-complementary target DNA and single base mismatched DNAs were used as models to demonstrate the proof-of-concept.

And the sequences with double- or four-base mismatched are readily distinguishable.

A dynamic sensing range of 1 pM to 1 nM is reported, and a limit of quantification (LOQ) of 2.03×10−13 M is deduced, with selectivity to single-RNA-base mismatched sequences.

This Bi2S3-based photoelectrochemical sensor possessed excellent photoelectron property and presented high detection specificity, even distinguishing single-base mismatched sequences.

For multiplex analysis detection, the nanocomplex of 1 nM in PBS buffer was treated with the Tubb3 targets (single-base mismatched or complementary DNA targets) or Fox3 targets (single-base mismatched or complementary DNA targets) at various concentrations of 0, 2, 5, 10, 25, 50, 100, and 200 nM.

The E-DNA sensor could differentiate the complete complementary DNA sequence, single-base mismatch DNA sequence and three-base mismatched DNA sequence, indicating a good selectivity.