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Since the transferred methyl group of the cofactor is in a pocket beneath the enzyme surface, the targeted guanine base has to flip out for methylation.
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"It has to flip over".
"You just have to flip that switch," Allen said.
You have to flip your colors".
When the butter begins to bubble and the base has turned golden, flip the pancakes over.
"They had to actually flip the switch," he said.
Google has nothing to flip.
And he has nothing to flip about".
"You've got to flip it.
A similar type of interaction, between a lysine residue and the 5′-phosphate next to the extrahelical base, has been described for base-flipping enzymes.
In particular, the role of c-FLIP has to be determined in the context of chains: what is the exact inhibitory mechanism of c-FLIP, whether c-FLIP-binding terminates the DED chain or promotes chain elongation.
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