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Two other positions (ns-SNPs 2 and 3) also show base frequency differences between SC and NBH and in the comparisons of all populations were identified as under selection by both likelihood ratio tests and AMOVA-FST.
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AIMs are markers selected based on their frequency differences between populations from different geographic regions.
The pairwise Nei's population genetic distances were calculated based on gene frequency differences between populations, and these distances were then compared to geographic distances between populations.
FST is a measure of genetic differentiation based on allele frequency differences between populations with values theoretically ranging from 0 (no differences in allele frequencies, panmictic populations) to 1 (populations share no alleles, no gene flow; Hartl and Clark 2006).
As some controls came from Israel and some from the United States, we first queried if we observed allele frequency differences between AJ controls based on origin.
Haplotype frequencies were also generated in PLINK based on the four COMT SNPs and both global and haplotype-specific tests were performed to test for frequency differences between disease status for maternal and fetal samples separately.
Nevertheless, several microsatellites displayed large frequency differences between the species.
> -wrap-foot> For each putative SNP, the criteria used for the selection of high-quality SNPs for KBioscience competitive allele-specific PCR (KASPar) assay included: (i) an SNP flanked by at least 50 bases on either side; (ii) frequency difference between the two genotypes ≥5; (iii) read depth ≥5.
The initial frequency difference between the two tones is large and is subsequently adjusted based on performance until a discrimination threshold is reached.
(b) Frequency difference between transmitted and received signals.
This method is based on the comparison of allele frequencies differences between populations.
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