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In patients with for whom the following values were measured, nonsurvivors had lower bicarbonates and greater base deficits (p = 0.02).
A national survey of pediatricians identified knowledge base deficits where nearly half of the respondents did not properly recognize and treat food-induced anaphylaxis [ 7].
In another prospective observational trial, Brill and colleagues studied 75 consecutive surgical intensive care patients with base deficits >2.0 mmol/l.
Unsurprisingly, a higher use of PACs and a greater mortality rate was noted in patients with high Injury Severity Score, greater initial base deficits and increasing age.
All five studies that evaluated metabolic changes found statistically significant increases in serum Cl, decreases in pH, and larger base deficits with standard Cl versus low Cl solutions.
When compared with lactate levels, values such as anion gaps, base deficits, pH and bicabonate levels are even less sensitive and specific.
Similar(50)
Base deficit distribution in the Study population.
Characteristics of patients in the fourth base deficit quartile (base deficit > 13) according to vital status at ICU discharge.
ICU mortality rate increased across base deficit quartiles (39.1, 59.2, 76.3 and 88.3%, p for trend < 0.001), and base deficit was independently associated with ICU mortality (p < 0.001).
Metabolic acidosis was defined by a positive base deficit (i.e., negative base excess).
We evidenced a severity-manner relationship between base deficit and survival to hospital discharge.
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