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We recommend base deficit as a sensitive test to estimate and monitor the extent of bleeding and shock (grade 1C).
We have previously studied the accuracy of base deficit as a surrogate for lactate in patients who are critically ill.
In addition, base deficit as a surrogate for serum lactate can be confounded by renal dysfunction and ketoacidosis.
Base deficit as a measure of metabolic acidosis was first proposed by Anderson and Engel in 1960[ 1].
We sought to better understand the utilization of base deficit as a clinical tool in the intra-operative setting.
The rationale for base deficit as a marker of severity of illness is based on the fact that as patients suffer from hemorrhage and hypotension, oxygen delivery becomes inadequate forcing the onset of anaerobic metabolism.
Similar(51)
Administration of THAM to 10 patients with acidosis and ALI caused significant improvements in arterial pH and base deficit, as well as a decrease in CO2 that was not adequately explained by the effects of ventilation [ 41].
Only one RCT used base deficit as an inclusion criterion [ 61].
We then selected patients who evidenced a metabolic acidosis at ICU admission, defined by a positive base deficit, as described above.
Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients.
Physicians may be aware that pH may add information to base deficit, as we observed that patients with acidemia had worse prognosis than those without.
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