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The lawyers are looking to base damages on products' sales.
If gross negligence is found, it would quadruple the base damages that BP could be forced to pay under the federal Clean Water Act.
A dispirited base damages a campaign at its foundation, and at its heart.
However, for any of the strains, it is difficult to know what types of base damages are the ones likely causing the increased reversion rates.
The damage induced by endogenous or exogenous insults can be base damages, single strand breaks (SSBs), DSBs, and intrastrand or interstrand cross-links [ 1].
Human apurinic/apyrimidinic endonuclease (APE1) is a multifunctional protein that has an essential role in DNA base excision repair involved in the repair of base damage, including oxidative base damages induced by platinating agents (Demple and Sung, 2005).
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The BER pathway begins with recognition of base damage by a DNA glycosylase, which removes the damaged base [7], [8].
Base damage typically halts DNA replication because most polymerases stall at damaged bases.
During the short-patch repair, after base damage, recognition occurs by a DNA glycosylase/lyase and subsequent cleavage of the damaged base occurs by AP endonuclease.
Therefore, the base damage award by the Court of Chancery amounted to $1.347 billion.
Cadet, J., Douki, T. & Ravanat, J.L. Oxidatively generated base damage to cellular DNA.
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CEO of Professional Science Editing for Scientists @ prosciediting.com